This month was a final step in dissertation writing. Described results might be fundamental for modern type of tissue analog preparation.Migration channels in form of straight lines obtained in ablation process provided the control of smooth muscle cells migration and spreading, mimicking their organization in blood vessel‘s wall. Poly-L-lysine/hyaluronic acid (PLL/HA) coatings cross-linked by carbodiimide or modified by silicon carbide nanoparticles introduction could be the most promising for surface functionalization of cardiovascular devices. Biomimetic multiscale surface functionalization of polyurethane/vinyl polychloride base materials improved their bio(hemo)compatibility. Presented results confirmed that significant improvement of blood contacting materials could be possible by fabrication of the multilayer structure mimicking the natural blood vessel‘s wall. The dissertation presented also a new approach in biomaterials hemocompatibility evaluation which seemed to be promising and would be developed in further experimental work.